Todd M. Lowe

Mailing Address

Education

• Ph.D., Molecular Genetics, August 1999
  Graduate School of Arts & Sciences
  Division of Biology & Biomedical Sciences
  Washington University, St. Louis, MO
  
  
• Bachelor of Arts in Biology, June 1992
  (concentration in Computer Science)
  Williams College, Williamstown, MA

Experience

• Assistant Professor, September 2001 - present
  Dept. of Computer Engineering
  University of California, Santa Cruz, CA
  
  
• Postdoctoral fellow, October 1999 - August 2001
  Stanford University School of Medicine, Stanford, CA
  David Botstein Lab, Dept. of Genetics
  
  
• Graduate Student, Molecular Genetics Program, 1993 - 1999
  Washington University, St. Louis, MO
  Thesis advisor: Dr. Sean Eddy, Dept. of Genetics
  
  
• Computer Specialist, Basic Research Branch, June 1992 - May 1993
  National Center for Biotechnology Information (NCBI), Bethesda, MD
  
  

Publications

• Speckmann, W.A., Li, Z.H., Lowe, T.M., Eddy, S.R., Terns, R.M., Terns, M.P. (2002) "Archaeal guide RNAs function in rRNA modification in the eukaryotic nucleus", Curr Biol 12, 199-203.
• Brown, J.W., Clark, G.P., Leader, D.J., Simpson, C.G., Lowe, T. (2001) "Multiple snoRNA gene clusters from Arabidopsis", RNA 7, 1817-32.
• Hamada, M., Huang, Y., Lowe, T.M., Maraia, R.J. (2001) "Widespread use of TATA elements in the core promoters for RNA polymerases III, II, and I in fission yeast", Mol. Cell Biol. 21, 6870-81.
• Dennis, P.P., Omer, A., Lowe, T. (2001) "A guided tour: small RNA function in Archaea", Mol. Microbiol. 40, 509-519.
• Omer, A.D, Lowe, T.M., Russel, A.G., Ebhardt, H., Eddy, S.R., Dennis, P.P. (2000) "Homologues of Small Nucleolar RNAs in Archaea", Science 288, 517-522.
• Lowe, T.M. & Eddy, S.R. (1999) "A Computational Screen for Methylation Guide snoRNAs in Yeast", Science 282, 1168-1171.
• Dunbar, D.A., Wormsley, S., Lowe, T.M., Baserga S.J. (2000) "Fibrillarin-associated Box C/D Small Nucleolar RNAs in Trypanosoma brucei: Sequence Conservation and Implications for 2'-O-ribose Methylation of rRNA", J. Biol. Chem. 275, 14767-14776.
• Lowe, T.M. & Eddy, S.R. (1997) "tRNAscan-SE: a program for improved transfer RNA detection in genomic sequence", Nucleic Acids Research 25, 955-964.
• Dieffenbach, C.W., Lowe, T.M., Dveksler, G.S. (1995) "General Concepts for PCR Primer Design", PCR Primer: A Laboratory Manual, Dieffenbach, C.W., Dveksler, G.S., eds, pp. 133-142. CSHL Press, Plainview, NY.
• Boguski, M.S., Lowe T.M., Tolstoshev, C.M. (1993) "dbEST -- database for expressed sequence tags", Nature Genetics 4: 332-3.
• Lowe, T.M., Sharefkin, J., Yang, S.Q., Dieffenbach, C.W. (1990) "A computer program for selection of oligonucleotide primers for the polymerase chain reaction", Nucleic Acids Research 18, 1757-1761.

Co-authorship for complete genome analysis of tRNA and/or snoRNA genes:

• Ng et al. (2000) "Genome sequence of Halobacterium species NRC-1", PNAS USA 97, 12176-81.
• The Arabidopsis Genome Initiative (2000) "Analysis of the genome sequence of the flowering plant Arabidopsis thaliana", Nature 408, 796-815.
• International Human Genome Sequencing Consortium (2001) "The Human Genome: Initial Sequencing and Analysis", Nature 409, 860-921.
• Wood et al. (2002) "The genome sequence of Schizosaccharomyces pombe", Nature 414, 871-880.